Texans vs. 49ers 2025 Prediction, Odds, Picks
The Houston Texans (2-4) are favored by 2.5 points against the San Francisco 49ers (5-2) on October 26, 2025, with kickoff at 1 p.m. ET, airing on FOX. The total points for the matchup is set at 42.5.
Texans vs. 49ers Odds & Betting Lines
Updated as of October 26, 2025, 12:33 p.m. ET:
- Favorite: Texans
- Spread: -2.5
- Spread Odds: -120
- Underdog: 49ers
- Spread Odds: +100
- Total: 42 top online casino philippines.5
- Over Odds: -109
- Under Odds: -121
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Texans vs. 49ers Prediction & Pick
- Pick ATS: Texans (-2.5)
- Pick OU: Under (42 bk8 legit.5)
Prediction: Texans 21 – 49ers 18
How to Watch Houston vs. San Francisco
Game Date: Sunday, October 26, 2025
Time: 1 p.m. ET
Venue: NRG Stadium
Location: Houston, Texas
TV: Watch on FOX
Streaming: FOXSports.com, FOX Sports App, and FOX One (Try free for 7 days)
Texans vs. 49ers Recent Matchups
In their last two encounters, the San Francisco 49ers have secured two victories over the Houston Texans. 777pub 555 During these matchups, San Francisco has outscored Houston 49 to 23.
Houston Betting Info
The Texans have achieved two wins against the spread in six games this season and have covered the spread twice (2-1 ATS) as at least 2.5-point favorites. Out of six games, Houston has resulted in the over hitting just two times (33.3%). As moneyline favorites, the Texans have a 66.7% victory rate (2-1). The implied win probability for Houston based on the moneyline is 60.8%.
Texans Stats
Stat | Average (Total) | Rank
- Pass yards: 198.2 (1,189) – 23
- Rush yards: 106.2 (637) – 18
- Points scored: 21.2 (127) – 27
- Pass yards against: 179.0 (1,074) – 5
- Rush yards against: 95.2 (571) – 10
- Points allowed: 14.7 (88) – 1
Houston’s Key Players
Offense: C.J. Stroud has tallied 1,305 passing yards, nine touchdowns, and four interceptions this season mwplay888.ner. He has completed 64.8% of his passes, averaging 217.5 yards per game. He has rushed for 147 yards, averaging 24.5 rushing yards per game. Nico Collins leads in receptions with 339 yards and three touchdowns.
Defense: Will Anderson Jr. leads the Texans with 4.0 sacks, while Jalen Pitre contributes with 31 tackles and three interceptions. Kamari Lassiter also stands out with 38 tackles this season.
San Francisco Betting Info
This year, the 49ers have covered the spread four times out of seven games (4-3-0) and have one against-the-spread win as underdogs of 2.5 points. San Francisco’s games have gone over the total four times this season, with a 43.5% implied chance of victory based on the moneyline.
49ers Stats
Stat | Average (Total) | Rank
- Pass yards: 271.3 (1,899) – 1
- Rush yards: 95.3 (667) – 24
- Points scored: 20.7 (145) – 21
- Pass yards against: 216.6 (1,516) – 18
- Rush yards against: 100.9 (706) – 12
- Points allowed: 19.7 (138) – 7
San Francisco’s Key Players
Offense: Christian McCaffrey leads the 49ers with three rushing touchdowns and 465 rushing yards. Meanwhile, Mac Jones has thrown for 1,404 yards this season. Jake Tonges has contributed with 224 receiving yards and three touchdowns.
Defense: Dee Winters has 43 tackles this season, while Bryce Huff stands out with 4.0 sacks. Marques Sigle also contributes significantly to the defense.
Are you excited to see how the Texans fare against the 49ers in this upcoming clash?